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Vytorin and the ENHANCE Study
The news that the drug Vytorin' may not be very effective for its advertised purpose has created a crisis for its manufacturers. Critics claim the results of a clinical trial of the medication's efficacy were released months, if not years, after the drug companies knew their product was not what they had originally claimed. Now, government oversight agencies are investigating the possibility that the drug's manufacturers are guilty of insider trading, medical test manipulation and/or false advertising. In addition, shareholders are upset and consumers are suing.
Vytorin contains two medications: Zocor' (simvastatin), manufactured by Merck & Co.; and Zetia' (ezetimibe), manufactured by Merck and Schering-Plough Corp. It is indicated for some patients who need to reduce total cholesterol and LDL (bad) cholesterol, and raise HDL (good) cholesterol.
Because Vytorin is more expensive than its component parts, Zocor and Zetia, health-care providers, government entities, insurers and patients have an interest in knowing if they are spending money wisely to obtain the combination drug. However, by late last year it was widely known that the test had long-since been completed, but Vytorin's makers continued to keep the results from the medical community and the general public.
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